Leukemic Transformation
نویسندگان
چکیده
منابع مشابه
Leukemic transformation in myelodysplastic syndrome: a review.
The literature was reviewed by us for leukemic transformation in the myelodysplastic syndrome (MDS). The factors reviewed included morphology, karyotype, in vitro cell culture, cellular oncogenes, genetic mutations and cell markers. Karyotypic abnormalities appeared to be most commonly associated with leukemic transformation in MDS. These abnormalities include: (1) Chromosomal abnormalities at ...
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A 9-year-old boy was diagnosed with stage III ALK-positive anaplastic large cell lymphoma (ALCL) with no evidence of bone marrow and central nervous system disease. Seven months later he had a normocytic anemia (hemoglobin 79 g/L), severe thrombocytopenia (platelets 15 109/L), and leukocytosis (white blood cell count 50.8 109/L). The automated differential showed neutrophils 28.5 109/L, monocyt...
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Cancer is now thought of as a fundamentally genetic disease, in that changes in the genome result in aberrant gene expression of oncogenes and tumor suppressor genes to promote oncogenesis. However, with our increasing knowledge of gene regulation, it is becoming obvious that changes in nucleotide sequence are not the sole mechanism for eliciting changes in transcription. An additional layer of...
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Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal expansion of myeloid progenitor cells. A major mechanistic theme in AML biology is the extensive collaboration among fusion oncoproteins, transcription factors, and chromatin regulators to initiate and sustain a transformed cellular state. A new study in this issue describes how the C/EBPα transcription factor is...
متن کاملGenomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.
Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor protein 53 (TP53) mutations are common in JAK2V617F-mutant, pos...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2004
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.3.1.537